The L,D-transpeptidation pathway is inhibited by antibiotics of the β-lactam class in Clostridioides difficile
Ana M. Oliveira Paiva, Pascal Courtin, Glenn Charpentier, Imane Oueled-Chama, Olga A. Soutourina, M.-P. Chapot, Peltier Johann
This study shows that cephalosporin resistance in C. difficile is due to inhibition of D,D-carboxypeptidases, not L,D-transpeptidases, and highlights the plasticity of PG biosynthesis.
iScience · Mar 16, 2025Peer-reviewedMicrobiology