Identification of novel Bromodomain inhibitors of Trypanosoma cruzi Bromodomain Factor 2 (TcBDF2) using a fluorescence polarization-base high-throughput assay
Esteban Carlos Serra, Luis Tavernelli, Imanol Peña, Elvio Rodríguez Araya, Romina Manarin, Juan Cantizani, Julio Martin, Juan Salamanca, Paul Bamborough, Félix Calderón, Raquel Gabarro
The paper develops a fluorescence polarization-based assay to identify bromodomain inhibitors of TcBDF2, finding 7 novel compounds that bind TcBDF2 with dissociation constants between 1 and 3 M.
Antimicrobial Agents and Chemotherapy · Jul 19, 2024Peer-reviewedMicrobiology