Elvio Rodríguez Araya

The paper identifies the structure and stoichiometry of bromodomain-containing complexes in Trypanosoma cruzi using proximity labeling and structure prediction.

MultimerMapper analyzes multimeric protein structure predictions to infer stoichiometry and interaction modes across different modeling contexts.

The paper develops a fluorescence polarization-based assay to identify bromodomain inhibitors of TcBDF2, finding 7 novel compounds that bind TcBDF2 with dissociation constants between 1 and 3 M.

The paper uses AlphaFold2 and genetic approaches to identify protein complexes in trypanosomatids, revealing structurally conserved and novel complexes involving MRG domain-containing proteins.