Esteban Carlos Serra

Proteomic mapping of novel tubulin post-translational modifications in Trypanosoma cruzi cytoskeleton

The paper identifies and maps novel tubulin post-translational modifications in Trypanosoma cruzi using proteomic analysis.

BDF6 deficiency severely compromises intracellular amastigotes development and infectivity in Trypanosoma cruzi

This study shows that BDF6 deficiency impairs intracellular development and infectivity of Trypanosoma cruzi parasites.

PKA/CIP4 SIGNALING REGULATES CIP4 RELOCATION IN ACTIVATED NATURAL KILLER CELLS

This study identifies PKA/CIP4 signaling as a mechanism controlling CIP4 relocalization during NK cell activation, showing phosphorylation at T225 regulates its spatial distribution.

Structural Insights into Bromodomain-Containing Complexes from Trypanosoma cruzi Revealed by Proximity Labeling and Stoichiometric Space Exploration

The paper identifies the structure and stoichiometry of bromodomain-containing complexes in Trypanosoma cruzi using proximity labeling and structure prediction.

Context-Dependent Protein Structure Prediction Analysis and Stoichiometry Inference with MultimerMapper

MultimerMapper analyzes multimeric protein structure predictions to infer stoichiometry and interaction modes across different modeling contexts.

Identification of novel Bromodomain inhibitors of Trypanosoma cruzi Bromodomain Factor 2 (TcBDF2) using a fluorescence polarization-base high-throughput assay

The paper develops a fluorescence polarization-based assay to identify bromodomain inhibitors of TcBDF2, finding 7 novel compounds that bind TcBDF2 with dissociation constants between 1 and 3 M.

Deciphering divergent trypanosomatid nuclear complexes by analyzing interactomic datasets with AlphaFold2 and genetic approaches

The paper uses AlphaFold2 and genetic approaches to identify protein complexes in trypanosomatids, revealing structurally conserved and novel complexes involving MRG domain-containing proteins.