Metabolic alterations drive inflammatory phenotypes in CHIP-associated heart failure
Siavash Mansouri, Inga Hemmerling, Golnaz Hesami, Sebastian Cremer, Klara Kirschbaum, Stephan Klatt, Fatemeh Behjati Ardakani, Marcel H. Schulz, Xue Li, Marina Scheller, Carsten Müller‐Tidow, Philipp Friedrich Arndt, Stefan Günther, Manju Padmasekar, Mario Looso, , Soni Savai Pullamsetti
This study shows that DNMT3A mutations in CHIP lead to metabolic changes in macrophages that drive inflammation, and targeting these changes can improve heart failure outcomes.
bioRxiv · Jul 30, 2024 · PreprintMolecular Biology