Siavash Mansouri

This study shows that loss of the Y chromosome in lung adenocarcinoma causes epigenetic and transcriptomic changes that increase lineage plasticity and poor clinical outcomes.

SAME improves multimodal spatial omics integration by allowing topological disruptions during alignment, enhancing cell-type accuracy and revealing hidden biological insights.

The paper identifies metabolic reprogramming in HIV-treated individuals that impairs monocyte migration and promotes M2-like macrophage polarization, enhancing HIV susceptibility.

This study shows that DNMT3A mutations in CHIP lead to metabolic changes in macrophages that drive inflammation, and targeting these changes can improve heart failure outcomes.