Artemether and Euphorbia Factor L9 suppress kynurenine production through distinct effects on Tryptophan metabolism.
Alina L. Capatina, Tomasz Czechowski, Charlotte Plunkett-Jones, Thierry Tonon, Ioannis Kourtzelis, Benjamin R. Lichman, William J. Brackenbury, Ian A. Graham, Dimitris Lagos
This study identifies artemether and EFL9 as inhibitors of kynurenine production through distinct mechanisms, offering potential new therapeutic approaches for targeting tryptophan metabolism.
Biochemical Journal · Mar 13, 2026Peer-reviewedCancer Biology