Dimitris Lagos

This study identifies artemether and EFL9 as inhibitors of kynurenine production through distinct mechanisms, offering potential new therapeutic approaches for targeting tryptophan metabolism.

This study shows LIMD1 is essential for effective miRNA targeting and repression by AGO2, revealing its role in expanding miRNA regulatory capacity beyond conserved targets.

This study shows Malat1 regulates cytokine expression in female Th2 cells by affecting early differentiation and IL2 response, but not in male cells.

This study shows PRMT activity regulates 3' UTR shortening in proliferating cells through alternative polyadenylation, impacting cancer and immune-related diseases.

This study shows that LIMD1 loss in lung cancer increases PD-L1 expression, promoting immune evasion and enhancing response to immune checkpoint inhibitors.

This study shows that β-glucan induces trained innate immunity in macrophages, reducing their efferocytosis of cancer cells and altering inflammatory responses.