A Second Drug Binding Site in P2X3
Trung Thanh Thach, KanagaVijayan Dhanabalan, Prajwal P. Nandekar, Seth Stauffer, Iring Heisler, Sarah K. Alvarado, Jonathan R. Snyder, Subramanian Ramaswamy
This study identifies a second drug-binding site in P2X3 receptors and shows camlipixant acts as an allosteric inhibitor, providing insights into its selectivity and mechanism of action.
Journal of Biological Chemistry · Dec 19, 2024Peer-reviewedBiochemistry