Author

Trung Thanh Thach

Purdue University West LafayetteORCID 0000-0001-8395-0623Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

KanagaVijayan DhanabalaniD· 2 shared Subramanian RamaswamyiD· 2 shared Gurunath RamanathaniD· 1 shared Iring Heisler· 1 shared Jane R. AllisoniD· 1 shared Jonathan R. SnyderiD· 1 shared Prajwal P. NandekariD· 1 shared Sarah K. AlvaradoiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiophysics

KanagaVijayan DhanabalanORCID

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2 papers

Recent·Most cited

BiophysicseLifePeer-reviewedSep 28, 2026

Bifunctional Architecture Enables Substrate Catalysis and Channeling in Paracoccus TMAO Demethylase

Trung Thanh Thach, KanagaVijayan Dhanabalan, Shiwangi Maurya…·Subramanian Ramaswamy

This study reveals a bifunctional mechanism in TMAO demethylase where HCHO is channeled from a catalytic core to a THF-binding site, linking TMAO demethylation with one-carbon transfer.

DOI 10.7554/elife.109964.4

structural biologyexperimental assay

𝕏 PostBluesky

BiochemistryJournal of Biological ChemistryPeer-reviewedDec 19, 2024

A Second Drug Binding Site in P2X3

Trung Thanh Thach, KanagaVijayan Dhanabalan, Prajwal P. Nandekar…·Subramanian Ramaswamy

This study identifies a second drug-binding site in P2X3 receptors and shows camlipixant acts as an allosteric inhibitor, providing insights into its selectivity and mechanism of action.

13 citations

humancryo-EM

𝕏 PostBluesky