Subramanian Ramaswamy

This study reveals a bifunctional mechanism in TMAO demethylase where HCHO is channeled from a catalytic core to a THF-binding site, linking TMAO demethylation with one-carbon transfer.

This study identifies the GABA shunt's role in maintaining redox balance in Drosophila blood progenitors by regulating TCA cycle activity and GSH synthesis.

This study identifies a second drug-binding site in P2X3 receptors and shows camlipixant acts as an allosteric inhibitor, providing insights into its selectivity and mechanism of action.

The paper reports the structures of SiaQM from Fusobacterium nucleatum with and without Neu5Ac, revealing interactions and transport mechanisms.

This study shows that Drosophila larval macrophages reprogram their metabolism in response to high sugar diets, with mixed effects on growth, where lipogenic shifts promote growth but are insufficient to counteract other metabolic changes.

The paper reports the cryo-EM structure of a TRAP transporter and elucidates its mechanism of sodium-driven substrate uptake.