A transcriptional constraint mechanism limits the homeostatic response to activity deprivation in mammalian neocortex
Vera Valakh, Derek L. Wise, Xiaoyue Aelita Zhu, Mingqi Sha, Jaidyn Fok, Stephen D. Van Hooser, Robin Schectman, Isabel Cepeda, Ryan Kirk, Sean M. O'Toole, Sacha B. Nelson
The paper shows that PARbZIP transcription factors constrain homeostatic plasticity in the mammalian neocortex, preventing excessive responses to activity deprivation.
eLife · Feb 7, 2023Peer-reviewedNeuroscience