Author

Sean M. O'Toole

Brandeis UniversityORCID 0000-0001-8617-5095Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Assay:electronic health records· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Derek L. WiseiD· 1 shared Georg B. KelleriD· 1 shared Hassana K. OyiboiD· 1 shared Isabel Cepeda· 1 shared Jaidyn Fok· 1 shared Mingqi ShaiD· 1 shared Robin Schectman· 1 shared Ryan Kirk· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperNeuroscience

Derek L. WiseORCID

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2 papers

Recent·Most cited

NeuroscienceeLifePeer-reviewedFeb 7, 2023

A transcriptional constraint mechanism limits the homeostatic response to activity deprivation in mammalian neocortex

Vera Valakh, Derek L. Wise, Xiaoyue Aelita Zhu…·Sacha B. Nelson

The paper shows that PARbZIP transcription factors constrain homeostatic plasticity in the mammalian neocortex, preventing excessive responses to activity deprivation.

24 citations

mouseelectronic health records

𝕏 PostBluesky

NeurosciencebioRxivPreprintJul 20, 2022

Prediction error neurons in mouse cortex are molecularly targetable cell types

Sean M. O'Toole, Hassana K. Oyibo, Georg B. Keller

The paper identifies transcriptionally distinct cell types in mouse visual cortex associated with positive and negative prediction error responses and validates them using genetic tools.

21 citations

mousescRNA-seq

𝕏 PostBluesky