Vera Valakh

This paper introduces Perturb-FISH, a method combining spatial transcriptomics and CRISPR screening to study transcriptional circuits, showing intracellular and intercellular effects in immune and neurological contexts.

CellMincer is a self-supervised deep learning method for denoising voltage imaging data, achieving significant noise reduction and improved functional phenotype separation.

The paper investigates how prolonged activity deprivation in mouse cortical slices affects synaptic and cellular properties, finding increased synaptic strength and reduced synaptic density.

This study develops a rapid, scalable method to generate functional human astrocytes from pluripotent stem cells using NGN2 induction, showing high homogeneity and disease relevance.

The paper shows that PARbZIP transcription factors constrain homeostatic plasticity in the mammalian neocortex, preventing excessive responses to activity deprivation.

The paper shows that astrocyte-neuron interactions enhance synaptic gene expression in neurons and correlate with schizophrenia risk genes.

This study investigates how the 22q11.2 deletion affects gene expression in neural progenitor cells and neurons, linking it to schizophrenia risk through altered presynaptic gene products.