Author

Isabel De La Rosa

Johns Hopkins University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 1

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Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Anna Lourdes CruziD· 1 shared Aswathy Peethambaran MallikaiD· 1 shared Grace D. BurnsiD· 1 shared Margarita Tsapatsis· 1 shared Meghraj Singh BagheliD· 1 shared Philip C. WongiD· 1 shared Shaelyn R Marx· 1 shared Shuying SuniD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperNeuroscience

Anna Lourdes CruzORCID

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1 paper

Recent·Most cited

Depletion of TDP-43 exacerbates tauopathy-dependent brain atrophy by sensitizing vulnerable neurons to caspase 3-mediated endoproteolysis of tau in a mouse model of Multiple Etiology Dementia

Meghraj Singh Baghel, Grace D. Burns, Margarita Tsapatsis, Aswathy Peethambaran Mallika, Anna Lourdes Cruz, Tianyu Cao, Xiaoke K. Chen, Isabel De La Rosa, Shaelyn R Marx, Yingzhi Ye, Shuying Sun, Tong Li, Philip C. Wong

This paper shows that TDP-43 loss-of-function worsens tauopathy in a mouse model by increasing caspase 3-mediated tau cleavage in vulnerable neurons, leading to greater brain atrophy.

bioRxiv · Jun 26, 2024 · PreprintNeuroscience