Depletion of TDP-43 exacerbates tauopathy-dependent brain atrophy by sensitizing vulnerable neurons to caspase 3-mediated endoproteolysis of tau in a mouse model of Multiple Etiology Dementia
Meghraj Singh Baghel, Grace D. Burns, Margarita Tsapatsis, Aswathy Peethambaran Mallika, Anna Lourdes Cruz, Tianyu Cao, Xiaoke K. Chen, Isabel De La Rosa, Shaelyn R Marx, Yingzhi Ye, Shuying Sun, Tong Li, Philip C. Wong
This paper shows that TDP-43 loss-of-function worsens tauopathy in a mouse model by increasing caspase 3-mediated tau cleavage in vulnerable neurons, leading to greater brain atrophy.
bioRxiv · Jun 26, 2024 · PreprintNeuroscience