Detection of deleterious on-target effects after HDR-mediated CRISPR editing
Isabel Weisheit, Joseph A. Kroeger, Rainer Malik, Julien Klimmt, Dennis Crusius, Angelika Dannert, Martin Dichgans, Dominik Paquet
The paper identifies deleterious on-target effects in CRISPR-edited human stem cells and introduces qgPCR and sequencing tools to detect them reliably.
Cell Reports · May 1, 2020Peer-reviewedGenomics