Author

Angelika Dannert

LMU KlinikumORCID 0000-0002-0902-3044Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:variant calling· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Dominik PaquetiD· 3 shared Judit González-GallegoiD· 2 shared Julien KlimmtiD· 2 shared Ana Melo de Farias· 1 shared Audrey CouloniD· 1 shared Benjamin Grenier‐BoleyiD· 1 shared Brigitte NuscheriD· 1 shared Bruno Neiva-Queirós· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersGenetics

Dominik PaquetORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The Alzheimer's disease-associated rs28834970 variant in PTK2B impairs electrical activity and regulates Tau phosphorylation and APP processing in human neuronal cultures

Nina lannette-Weimann, Marlène Huyvaert, Floriane Limoge, Morgane Lemaire, Vance Difan Gao, Florence Maurier, Karine Guyot, Charlotte Henocq, Audrey Coulon, Valérie Buiche, Florian Rabiller, Nad’a Majerníková, Pauline Walle, Sophie Desnoulez-Salomé, Bruno Neiva-Queirós, , Julie Dumont

This study identifies the rs28834970 variant in PTK2B as a risk factor for Alzheimer's disease, showing it impairs PYK2 function, increases Tau phosphorylation, and alters APP processing in human neuronal cultures.

bioRxiv · Oct 30, 2026 · PreprintGenetics

A reproducible human brain tissue model to study physiological and disease-associated microglia phenotypes

Julien Klimmt, Carolina Cardoso Gonçalves, Jessica Valentina Montgomery, Stephan A. Müller, Merle Bublitz, Severin Filser, Lars Paeger, Brigitte Nuscher, Angelika Dannert, Sigrun Roeber, Veronica M. Pravatà, Martina Schifferer, Joshua James Shrouder, Nathalie Schulz, Judit González-Gallego, , Dominik Paquet

This paper develops a 3D cortical brain tissue model with mature microglia that recapitulates Alzheimer's disease hallmarks and enables study of microglia phenotypes.

bioRxiv · Jan 21, 2026 · PreprintNeuroscience

Detection of deleterious on-target effects after HDR-mediated CRISPR editing

Isabel Weisheit, Joseph A. Kroeger, Rainer Malik, Julien Klimmt, Dennis Crusius, Angelika Dannert, Martin Dichgans, Dominik Paquet

The paper identifies deleterious on-target effects in CRISPR-edited human stem cells and introduces qgPCR and sequencing tools to detect them reliably.

Cell Reports · May 1, 2020Peer-reviewedGenomics