Julien Klimmt

This paper develops a 3D cortical brain tissue model with mature microglia that recapitulates Alzheimer's disease hallmarks and enables study of microglia phenotypes.

This study shows that Dnmt3a1, but not Dnmt3a2, is required for hippocampus-dependent memory through its regulation of Nrp1.

This study shows that TREM2 deficiency reduces microglial hyperactivation in GRN-deficient models but does not rescue lysosomal dysfunction or neurodegeneration biomarkers.

The paper identifies deleterious on-target effects in CRISPR-edited human stem cells and introduces qgPCR and sequencing tools to detect them reliably.