Martin Dichgans

Reversible hypervascularization drives cognitive decline and blood-brain barrier damage during aging

The paper identifies a hypervascular, BBB-compromised state in aging mice linked to cognitive decline and shows pharmacological stabilization improves vascular and cognitive outcomes.

Endothelial Arf6 sustains capillary electrical signaling and cerebral blood flow through PIP2 regeneration and activation of Kir2.1 channels.

This study shows that Arf6 maintains PIP2 levels in capillary endothelial cells, sustaining Kir2.1 channel activity and functional hyperemia, and identifies Arf6 as a therapeutic target for cerebral blood flow restoration.

The Ethnic/Racial Variations of Intracerebral Hemorrhage Genetics (ERICH-GENE) Study Protocol

ERICH-GENE collects and analyzes genomic and neuroimaging data from over 10,000 multi-ethnic ICH cases to identify genetic risk factors and trans-ethnic variation in ICH.

APOE stratified genome-wide association studies provide novel insights into the genetic etiology of Alzheimers's disease

This study performs APOE-stratified GWAS to uncover genetic mechanisms underlying Alzheimer's disease risk and response to therapies.

The Genomic Architecture of Circulating Cytokine Levels Points to Drug Targets for Immune-Related Diseases

This study identifies genetic variants associated with circulating cytokine levels and suggests potential drug targets for immune-related diseases.

Shared inflammatory glial cell signature after brain injury, revealed by spatial, temporal and cell-type-specific profiling of the murine cerebral cortex

The paper identifies a shared inflammatory glial cell signature after brain injury using spatial and single-cell transcriptomics in mice, showing common injury-regulated genes across astrocytes, microglia, and oligodendrocyte precursor cells.

Proteogenomic integration reveals CXCL10 as a potentially downstream causal mediator for IL-6 signaling on atherosclerosis

The paper uses proteogenomic integration to identify CXCL10 as a mediator of IL-6 signaling effects on atherosclerosis, showing its association with cardiovascular disease risk and lesion characteristics.

Genetically predicted on-statin LDL response is associated with higher intracerebral hemorrhage risk

This study uses Mendelian Randomization to show that a higher genetic response to statins is linked to increased intracerebral hemorrhage risk among statin users.

Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles

This GWAS identifies 123 migraine risk loci, including subtype-specific variants and novel targets, supporting neurovascular mechanisms in migraine.

Whole-exome sequencing in 16,511 individuals reveals a role of the HTRA1 protease and its substrate EGFL8 in brain white matter hyperintensities

The paper identifies rare variants in HTRA1 and its substrate EGFL8 associated with increased white matter hyperintensities using whole-exome sequencing data from 16,511 UK Biobank individuals.

Microbiota-derived short chain fatty acids promote Aβ plaque deposition

This study shows that microbiota-derived short chain fatty acids (SCFA) increase Aβ plaque deposition in Alzheimer's disease by promoting microglial activation and ApoE upregulation.

Modifiable lifestyle factors and risk of stroke: a Mendelian randomization analysis

This study uses Mendelian randomization to assess the causal effects of education, smoking, and BMI on stroke risk, finding independent associations with different stroke subtypes.

Diabetes mellitus, glycemic traits, and cerebrovascular disease: a Mendelian randomization study

This study uses Mendelian randomization to show that genetic predisposition to T2D and hyperglycemia increases risk of ischemic and small vessel stroke, with distinct effects of insulin resistance and beta-cell dysfunction.

Detection of deleterious on-target effects after HDR-mediated CRISPR editing

The paper identifies deleterious on-target effects in CRISPR-edited human stem cells and introduces qgPCR and sequencing tools to detect them reliably.

Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke

The paper develops a genomic risk score (metaGRS) for ischaemic stroke that outperforms existing risk factors in predicting stroke risk.

Gene-Based Analysis in HRC Imputed Genome Wide Association Data Identifies Three Novel Genes For Alzheimer’s Disease

The paper uses a novel gene-based analysis approach to identify three novel genes associated with Alzheimer’s disease using genome-wide association data.

The Subtype Specificity of Genetic Loci Associated with Stroke in 16,664 cases and 32,792 controls

The paper identifies subtype-specific genetic loci associated with stroke subtypes and finds heterogeneity in their effects across different stroke types.

Genetic variants related to antihypertensive targets inform drug efficacy and side effects

The paper uses genetic variants to investigate side effects and repurposing potential of antihypertensive drugs, finding a link between calcium channel blockers and increased diverticulosis risk.

In vivo widefield calcium imaging of the mouse cortex for analysis of network connectivity in health and brain disease

This paper introduces an improved widefield calcium imaging protocol for studying interhemispheric connectivity in mice, showing reduced connectivity after stroke and partial recovery over time.

Automated analysis of whole brain vasculature using machine learning

The paper develops a deep learning framework to analyze whole brain vasculature in cleared mouse brains, revealing new insights into vascular architecture and collateralization.

Common variant burden contributes significantly to the familial aggregation of migraine in 1,589 families

This study shows common genetic variants significantly contribute to migraine family clustering, with higher burden in familial cases compared to population-based cases.