Hepatocyte UBE4A protects against MASLD/MASH by maintaining ER homeostasis via UBXN4 interaction
Naga Lakshmi Challa, Vineet Babu, Molee Chakraborty, Matthew Hayes, Gaurav Kumar, Kyle S. McCommis, Craig W. Vander Kooi, Danielle Carpenter, Isabela Ramos, Shivankitha Kattekola, Ameya Padakanti, Shikara Patel, Kaitlyn Mills, Sanchita Gupta, Louise Lantier, , Anutosh Chakraborty
This study identifies Ube4A's role in protecting against MASLD/MASH by maintaining ER homeostasis through its interaction with UBXN4, highlighting potential therapeutic targets.
bioRxiv · Oct 13, 2026 · PreprintPhysiology