Craig W. Vander Kooi

Hepatocyte UBE4A protects against MASLD/MASH by maintaining ER homeostasis via UBXN4 interaction

This study identifies Ube4A's role in protecting against MASLD/MASH by maintaining ER homeostasis through its interaction with UBXN4, highlighting potential therapeutic targets.

Systemic hypoxia drives glycogen-fueled progression of lung adenocarcinoma

This study shows systemic hypoxia promotes lung adenocarcinoma progression by mobilizing glycogen via GAA, supporting tumor growth through metabolic remodeling.

A multi-organ spatial metabolomic atlas of exercising mice reveals neuronal Complex I as a convergent and sufficient axis for tau pathology reduction in PS19

This paper constructs a spatial metabolomic atlas of exercise in mice, identifies Complex I as a key target for reducing tau pathology, and shows that enhancing its activity mimics exercise's protective effects.

Metabolic Coherence of the Mouse Brain

The paper maps spatial metabolome coherence across mouse brain regions using MALDI imaging and optimal transport, showing preserved coherence in Alzheimer's model despite metabolic changes and demonstrating intervention effects.

Hyper-Glycosylation as a Central Metabolic Driver of Alzheimers Disease

This study identifies hyper-glycosylation as a driver of Alzheimer's disease through metabolic analysis and interventions, showing its impact on cognitive decline and mortality.

CIB2 function is distinct from Whirlin in the development of cochlear stereocilia staircase pattern

The paper investigates the distinct roles of CIB2 and whirlin in cochlear stereocilia development and shows that CIB2 has independent functions from whirlin in maintaining the staircase pattern.

MetaVision3D: Automated framework for the Generation of Spatial Metabolome Atlas in 3D

MetaVision3D converts serial 2D MALDI mass spectrometry imaging sections into a 3D spatial metabolome atlas using computer vision techniques.

Spatial Metabolome Lipidome and Glycome from a Single brain Section

The paper presents a method for simultaneous spatial analysis of metabolome, lipidome, and glycome from a single tissue section using mass spectrometry imaging and a computational framework called Sami.

Calcium and Integrin-binding protein 2 (CIB2) controls force sensitivity of the mechanotransducer channels in cochlear outer hair cells

This study investigates the role of CIB2 in mechanotransducer channels of cochlear outer hair cells, finding that a mutation alters channel properties and force sensitivity.

Functional Exploration of Conserved Sequences in the Distal Face of Angiotensinogen

This study investigates the functional role of conserved sequences in the loop and β-sheet regions of angiotensinogen, showing that mutations in either region individually have no effect, but combined mutations impair AGT secretion.

The Ruminococcus bromii amylosome protein Sas6 binds single and double helical α-glucan structures in starch.

This study presents the crystal structures of Sas6 and RbCBM74 bound to maltodecaose, showing their binding specificity for single and double helical α-glucan structures in starch.