Kyle S. McCommis

This study identifies Ube4A's role in protecting against MASLD/MASH by maintaining ER homeostasis through its interaction with UBXN4, highlighting potential therapeutic targets.

This study identifies a non-canonical cGAS-STING pathway that drives aging and progeria by promoting inflammation and senescence, and shows that targeting this pathway can improve aging-related phenotypes.

This study shows that loss of the mitochondrial pyruvate carrier in the heart leads to glycogen accumulation and heart failure, which can be reversed by inhibiting glycogen synthesis or a ketogenic diet.

This study shows that a ketogenic diet improves heart failure in mice without requiring increased cardiac ketone metabolism.

This study predicts the structure of the human mitochondrial pyruvate carrier and investigates inhibitor binding to guide the development of more specific therapeutic agents.

This paper identifies BIOIO-1001 as a dual mTOR/NAD+ acting gerotherapy that reduces metabolic derangements, inflammation, and fibrosis in NASH and ALS models.