Induction of ferroptotic and amyloidogenic signatures linked to Alzheimers disease by chemically distinct air pollutants
Kristina Shkirkova, Naomi S. Sta Maria, Herbert Anson, Yashar Aghaei, Mohammad Mahdi Badami, Ararat Chakhoyan, José A. Godoy-Lugo, Claire S Chung, Salma Durra, Angela M. Tang-Tan, Lifu Zhao, Alexandra N. Demetriou, Manuel Morales, Sindhu Daggupati, Isabella Bent, , Max Andrew Thorwald
This study shows that metal-rich air pollutants induce ferroptosis and amyloidogenic pathways linked to Alzheimer's disease through shared transcriptional and oxidative mechanisms.
Redox Biology · Sep 15, 2026Peer-reviewedNeuroscience