Bérénice Anath Benayoun

Temporal control of mitochondrial mutagenesis reveals the fate of mtDNA mutations with age

This study shows that mtDNA mutations arising early in life drive age-related pathologies and that mitochondrial fusion modulates their selection, suggesting interventions targeting fusion could slow aging.

Induction of ferroptotic and amyloidogenic signatures linked to Alzheimers disease by chemically distinct air pollutants

This study shows that metal-rich air pollutants induce ferroptosis and amyloidogenic pathways linked to Alzheimer's disease through shared transcriptional and oxidative mechanisms.

Acute LINE-1 overexpression rewires the transcriptome, proteome and secretome of primary human fibroblasts

This study shows that acute LINE-1 overexpression in human fibroblasts causes widespread changes in transcriptome, proteome, and secretome, affecting cell cycle and interferon pathways, beyond retrotransposition.

Reversible, Sexually Dimorphic Sympathetic Aging: Distal Axon Withdrawal Shaped by Prepubertal Gonadal Influences

This study shows that sympathetic aging is reversible and sexually dimorphic, with male mice showing greater denervation due to gonadal influences and target environment changes.

Form and function of actin impacts actin health and aging.

This study investigates how actin structure and function affect aging in C. elegans and finds that actin dysfunction accelerates aging hallmarks and correlates with human age-related decline in gait speed.

17α-Estradiol Confers Limited Protection Against APOE4 Phenotypes in Middle-Aged Female Mice

This study tests if 17α-estradiol benefits APOE4 females similarly to males, finding limited CNS improvements but some metabolic benefits in APOE4 females.

MOTS-c Coordinates Inter-Organellar Proteostasis for Adaptation to Chronic Metabolic Stress

This study identifies MOTS-c as a mitochondrial-derived peptide that coordinates inter-organellar proteostasis to enable adaptation to chronic metabolic stress.

Shared and niche-specific transcriptional signatures of macrophage aging revealed by a cross-tissue meta-analysis

This study identifies shared and niche-specific transcriptional changes in macrophages across tissues and sexes using a meta-analysis of RNA-sequencing datasets.

A multi-omic atlas in the African turquoise killifish reveals increased glucocorticoid signaling as a hallmark of brain aging

This study creates a multi-omic atlas of brain aging in African turquoise killifish, identifying glucocorticoid signaling activation as a key feature of aging and showing its inhibition can reverse aging phenotypes.

Estropausal gut microbiota transplant improves measures of ovarian function in adult mice

This study shows that transferring gut microbiota from young and estropausal mice improves ovarian function and fertility in adult mice.

Single-nuclei RNA-sequencing uncovers sexually divergent exercise signatures partially mimicked by TFEB overexpression in mouse skeletal muscle

This study uses single-nucleus RNA-sequencing to compare transcriptional changes in male and female mouse skeletal muscle during exercise and TFEB overexpression, revealing sex-specific metabolic adaptation mechanisms.

The RNA exosome maintains cellular RNA homeostasis by controlling transcript abundance in the brain

This study uses a Drosophila model to show that RNA exosome mutations disrupt brain transcriptomes and cause neurodegeneration by altering rRNA processing.

A multi-omics analysis of human fibroblasts overexpressing an Alu transposon reveals widespread disruptions in aging-associated pathways

This study shows that overexpressing an Alu transposon in human fibroblasts causes widespread disruptions in aging-related pathways across transcriptome, proteome, and secretome.

Distinct mechanisms of non-autonomous UPRER mediated by GABAergic, glutamatergic, and octopaminergic neurons.

The paper identifies distinct roles of GABAergic, glutamatergic, and octopaminergic neurons in mediating non-autonomous UPRER through transcriptomic and functional analyses in C. elegans.

Single-cell exploration of ovarian aging across mammalian models

This study analyzes ovarian aging across species using single-cell RNA-seq data to identify conserved and species-specific features and suggests drug repurposing candidates.

Neutrophil TLR2 signaling promotes lipid accumulation and vascular plaque growth

This study shows that neutrophil TLR2 signaling promotes lipid uptake and storage, contributing to atherosclerotic plaque growth.

Mouse peritoneal macrophages undergo female-specific remodeling with aging driven by both hormone-dependent and -independent mechanisms

This study identifies sex-specific aging-related changes in mouse peritoneal macrophages, driven by both hormone-dependent and -independent mechanisms.

Systematic characterization of the ovarian landscape across mouse menopause models

This study systematically compares three mouse menopause models to identify shared and model-specific features of follicle loss and endocrine disruption using single-cell transcriptomics and machine learning.

Down syndrome with Alzheimers disease brains have increased iron and associated lipid peroxidation consistent with ferroptosis

The paper examines iron levels and lipid peroxidation in DSAD brains, finding increased iron and lipid damage compared to AD and controls, suggesting ferroptosis involvement.

Sex-dimorphic gene regulation in murine macrophages across niches

The paper identifies sex-dimorphic gene expression patterns in mouse macrophages across niches, finding three consistently differentially expressed genes and female-biased pathways related to extracellular matrix components.

Iron associated lipid peroxidation in Alzheimers disease is increased in lipid rafts with decreased ferroptosis suppressors, tested by chelation in mice

The paper investigates iron-mediated toxicity in Alzheimer's disease by analyzing postmortem brain tissue and ApoE4 mice, finding increased lipid peroxidation and decreased antioxidants in lipid rafts, which are reduced by iron chelation.

Multi-ancestry GWAS reveals loci linked to human variation in LINE-1- and Alu-insertion numbers

This study uses a multi-ancestry GWAS to identify genetic loci associated with variation in LINE-1 and Alu insertion numbers, highlighting potential regulatory mechanisms and disease links.

Ilastik: a machine learning image analysis platform to interrogate stem cell fate decisions across multiple vertebrate species

The paper introduces Ilastik, a machine learning tool for analyzing stem cell fate decisions in vertebrate species, showing it outperforms manual counting in accuracy and speed.

The cGAS-STING pathway is an in vivo modifier of genomic instability syndromes

This study models DDR syndromes in killifish and shows that cGAS-STING pathway activation contributes to disease phenotypes, with cGAS mutation partially rescuing defects.

An eQTL-based Approach Reveals Candidate Regulators of LINE-1 RNA Levels in Lymphoblastoid Cells

The paper identifies candidate regulators of LINE-1 RNA levels in lymphoblastoid cells using eQTL analysis and validates some candidates experimentally.

Protection against APOE4-associated aging phenotypes with the longevity-promoting intervention 17α-estradiol in male mice

This study shows that 17α-estradiol improves aging outcomes in APOE4 mice more than APOE3 mice, suggesting a genotype-dependent benefit of the intervention.

Transcriptional profiling of aging tissues from female and male African turquoise killifish

This paper provides a transcriptional dataset of aging tissues from African turquoise killifish, showing age has a greater impact than sex on gene expression and TE transcription.

Widespread sex-dimorphism across single-cell transcriptomes of adult African turquoise killifish tissues

The paper creates a single-cell gene expression atlas of adult African turquoise killifish tissues, revealing widespread sex-dimorphic gene expression, particularly in the liver, and identifies molecular markers for sex identity.

Age-maintained human neurons demonstrate a developmental loss of intrinsic neurite growth ability

Directly-reprogrammed human neurons show reduced neurite growth ability with age, mirroring rodent developmental patterns.

Transcript errors generate a continuous stream of amyloid and prion-like proteins in human cells

The paper shows transcript errors generate amyloid and prion-like proteins in human cells, linking DNA damage to aging and disease.