Caleb E. Finch

Induction of ferroptotic and amyloidogenic signatures linked to Alzheimers disease by chemically distinct air pollutants

This study shows that metal-rich air pollutants induce ferroptosis and amyloidogenic pathways linked to Alzheimer's disease through shared transcriptional and oxidative mechanisms.

17α-Estradiol Confers Limited Protection Against APOE4 Phenotypes in Middle-Aged Female Mice

This study tests if 17α-estradiol benefits APOE4 females similarly to males, finding limited CNS improvements but some metabolic benefits in APOE4 females.

Single cell profiling reveals GSM-15606 attenuates air pollution-induced inflammation and preserves hippocampal neurogenesis

The paper uses single-cell RNA sequencing to show GSM-15606 reduces inflammation and preserves neurogenesis in the hippocampus of mice exposed to air pollution.

Chimpanzee and human ApoE isoforms differ in the stimulation of neurite differentiation consistent with structural predictions with relevance to brain development and aging

The paper shows chimpanzee ApoE isoforms increase neurite number but reduce neurite length compared to human ApoE isoforms, suggesting functional similarity to ApoE4.

Down syndrome with Alzheimers disease brains have increased iron and associated lipid peroxidation consistent with ferroptosis

The paper examines iron levels and lipid peroxidation in DSAD brains, finding increased iron and lipid damage compared to AD and controls, suggesting ferroptosis involvement.

Iron chelation by oral deferoxamine treatment decreased brain iron and iron signaling proteins

The paper shows oral DFO reduces brain iron and iron-related proteins in mice, suggesting potential therapeutic benefits for early-stage Alzheimer's.

Iron associated lipid peroxidation in Alzheimers disease is increased in lipid rafts with decreased ferroptosis suppressors, tested by chelation in mice

The paper investigates iron-mediated toxicity in Alzheimer's disease by analyzing postmortem brain tissue and ApoE4 mice, finding increased lipid peroxidation and decreased antioxidants in lipid rafts, which are reduced by iron chelation.

Protection against APOE4-associated aging phenotypes with the longevity-promoting intervention 17α-estradiol in male mice

This study shows that 17α-estradiol improves aging outcomes in APOE4 mice more than APOE3 mice, suggesting a genotype-dependent benefit of the intervention.