A-LAVA: Detecting impact of germline variants on metabolic pathways in cancer genomes
Mansoureh Jalilkhany, Kiana Gallagher, Isabella Wehner, Phineas T. Hamilton, Sarah MacPherson, Sarah J. McPhedran, Farouk S. Nathoo, Julian J. Lum, Ibrahim Numanagić
A-LAVA identifies germline variants affecting metabolic pathways in cancer genomes through SNP, gene, and pathway-level analysis, improving accuracy by correcting for overlapping gene sets and reducing false positives.
bioRxiv · Aug 30, 2025 · PreprintBioinformatics