Julian J. Lum

PRDX1 regulates T cell effector function in the ovarian tumor microenvironment

This study identifies PRDX1 as a negative regulator of T cell effector function in the ovarian tumor microenvironment, showing its impact on cytokine production, metabolism, and viability.

Ambient mass spectrometry imaging enables spatial metabolomics of optimal cutting temperature compound (OCT)-embedded tumors

This paper demonstrates ambient mass spectrometry imaging of metabolites in OCT-embedded tumors, revealing spatial metabolic changes in a preclinical model.

Autophagy disruption primes CAR-T cell metabolism for sustained rejection of ovarian tumors

This study shows that disrupting autophagy in CAR-T cells enhances their metabolic activity and improves their ability to reject ovarian tumors in vivo.

Methionine regulates antitumor function of CD8⁺ T cells through polyamine synthesis

This study shows that methionine restriction affects CD8+ T cell function through polyamine synthesis, but does not improve antitumor efficacy in vivo.

A-LAVA: Detecting impact of germline variants on metabolic pathways in cancer genomes

A-LAVA identifies germline variants affecting metabolic pathways in cancer genomes through SNP, gene, and pathway-level analysis, improving accuracy by correcting for overlapping gene sets and reducing false positives.

Metabolic Vulnerabilities of Temozolomide-Resistant Glioblastoma Cells: Implications for Targeted Therapies and Overcoming Chemoresistance

The paper identifies metabolic vulnerabilities in TMZ-resistant glioblastoma cells, showing that iron reduction enhances the efficacy of TMZ through mechanisms involving Hif1, autophagy, and ROS.

A method to identify high consensus predictions of single-cell metabolic flux

This paper develops a method to identify high consensus predictions of single-cell metabolic flux by comparing two existing tools, Compass and scFEA, and shows they agree on metabolic processes in both healthy and pathological samples.