Sarah MacPherson

This study identifies PRDX1 as a negative regulator of T cell effector function in the ovarian tumor microenvironment, showing its impact on cytokine production, metabolism, and viability.

This study shows that methionine restriction affects CD8+ T cell function through polyamine synthesis, but does not improve antitumor efficacy in vivo.

A-LAVA identifies germline variants affecting metabolic pathways in cancer genomes through SNP, gene, and pathway-level analysis, improving accuracy by correcting for overlapping gene sets and reducing false positives.