Dietary Indoles Modulate Gut Barrier Integrity via the AhR-IL-22 Axis in ART-Treated SIV Infection
Siva Thirugnanam, Alison R. Van Zandt, Alexandra B. McNally, Victoria A Hart, Isabelle Berthelot, Lara A. Doyle‐Meyers, David A. Welsh, Andrew G. MacLean, Namita Rout
This study shows dietary indoles restore gut barrier function in SIV-infected macaques by reactivating the AhR-IL-22 pathway, reducing intestinal epithelial barrier disruption markers.
bioRxiv · Dec 8, 2025 · PreprintImmunology