Author

Andrew G. MacLean

Tulane UniversityORCID 0000-0002-0356-0674Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:rat· 3 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Alison R. Van ZandtiD· 3 shared Miranda D. HorniD· 2 shared Ahmad A. SaiediD· 1 shared Alexandra B. McNallyiD· 1 shared Cecily C. MidkiffiD· 1 shared David A. WelshiD· 1 shared Elise M. Frost· 1 shared Isabelle Berthelot· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersNeuroscience

Alison R. Van ZandtORCID

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3 papers

Recent·Most cited

Neuroinvasion by Simian Immunodeficiency Virus Triggers Glial Senescence and Accelerated Neurodegeneration

Miranda D. Horn, Cecily C. Midkiff, Alison R. Van Zandt, Ahmad A. Saied, Andrew G. MacLean

This study shows that SIV infection in rhesus macaques leads to increased p16 and decreased SIRT1, associated with neurodegeneration and aging markers in multiple brain regions.

bioRxiv · Dec 16, 2025 · PreprintNeuroscience

Dietary Indoles Modulate Gut Barrier Integrity via the AhR-IL-22 Axis in ART-Treated SIV Infection

Siva Thirugnanam, Alison R. Van Zandt, Alexandra B. McNally, Victoria A Hart, Isabelle Berthelot, Lara A. Doyle‐Meyers, David A. Welsh, Andrew G. MacLean, Namita Rout

This study shows dietary indoles restore gut barrier function in SIV-infected macaques by reactivating the AhR-IL-22 pathway, reducing intestinal epithelial barrier disruption markers.

bioRxiv · Dec 8, 2025 · PreprintImmunology

THC Reverses SIV-Induced Senescence in Astrocytes: Possible Compensatory Mechanism Against HIV Associated Brain Injury?

Alison R. Van Zandt, Miranda D. Horn, Tiffany A. Peterson, Sarah Y. Dickinson, Elise M. Frost, Andrew G. MacLean

This study shows THC protects astrocytes from HIV Tat-induced senescence and inflammation in rhesus macaques, but high-dose THC may harm glial survival.

Frontiers in Cellular Neuroscience · Sep 30, 2025Peer-reviewedNeuroscience