Author

Siva Thirugnanam

Tulane University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:host-pathogen & immune response· 2 Organism:rat· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:metabolomics· 1

Frequent Co-Authors

Namita RoutiD· 3 shared Jay RappaportiD· 2 shared Ahmad A. SaiediD· 1 shared Alexandra B. McNallyiD· 1 shared Alison R. Van ZandtiD· 1 shared Andrew G. MacLeaniD· 1 shared Brooke F. GraspergeiD· 1 shared Chen ZhengiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersImmunology

Namita RoutORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Persistent Activation of Monocytes/Macrophages and Cell Senescence in SIV-Infected Macaques on ART

Yilin Chen, Xiaofeng Ding, Sonalika Ray, Siva Thirugnanam, Robert V. Blair, Ahmad A. Saied, Sergiy Sukhanov, Jay K. Kolls, W. Y. KIM, Patrice Delafontaine, Jay Rappaport, Xuebin Qin, Namita Rout

This study shows that long-term ART in SIV-infected macaques reduces acute inflammation but maintains chronic macrophage and TLR-driven inflammation linked to vascular damage and aging.

Frontiers in Immunology · Mar 12, 2026Peer-reviewedImmunology

Dietary Indoles Modulate Gut Barrier Integrity via the AhR-IL-22 Axis in ART-Treated SIV Infection

Siva Thirugnanam, Alison R. Van Zandt, Alexandra B. McNally, Victoria A Hart, Isabelle Berthelot, Lara A. Doyle‐Meyers, David A. Welsh, Andrew G. MacLean, Namita Rout

This study shows dietary indoles restore gut barrier function in SIV-infected macaques by reactivating the AhR-IL-22 pathway, reducing intestinal epithelial barrier disruption markers.

bioRxiv · Dec 8, 2025 · PreprintImmunology

High IL-1β and IL-18 Levels Associate with Gut Barrier Disruption and Monocyte Activation During Chronic SIV Infection with Long-Term Suppressive Antiretroviral Therapy

Siva Thirugnanam, Chenxiao Wang, Chen Zheng, Brooke F. Grasperge, Prasun K. Datta, Jay Rappaport, Xuebin Qin, Namita Rout

This study links elevated IL-1β and IL-18 levels with gut barrier disruption and monocyte activation in SIV-infected macaques on long-term ART, suggesting a role in CVD and metabolic complications.

International Journal of Molecular Sciences · Aug 9, 2024Peer-reviewedImmunology