Development of metastases in mice induced by plasma sample collected during radiotherapy in patient with triple-negative breast cancer: Role of Rab4A
Benoît Paquette, Hélène Therriault, Isabelle C Gauthier, Sawyna Provencher, Sahar Naasri, Ayman J. Oweida, Sameh Geha, Pascale Labrecque, Jean‐Luc Parent
This study shows that downregulating RAB4A reduces TNBC cell invasion and metastasis, and plasma from a TNBC patient during radiotherapy enhances invasiveness, which is blocked by RAB4A downregulation.
bioRxiv · Jul 23, 2025 · PreprintCancer Biology