Selective impairment of long-term depression in accumbal D1R+ MSNs involves calcium-permeable AMPARs in early Alzheimer's disease
Nicolás Riffo-Lepe, Juliana González-Sanmiguel, Isaias Meza, Paulina Saavedra, Lorena Armijo‐Weingart, Helena Zambrano, Ailín Riquelme, Armando G. Salinas, Loreto San Martín, Luis Gerardo Aguayo
This study identifies a cell-type-specific synaptic mechanism in the nucleus accumbens linking early Aβ accumulation to circuit dysfunction in early Alzheimer's disease.
Neurobiology of Disease · Aug 7, 2026Peer-reviewedNeuroscience