Author

Luis Gerardo Aguayo

University of ConcepciónORCID 0000-0003-3160-1522Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:electronic health records· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Nicolás Riffo-LepeiD· 2 shared Ailín Riquelme· 1 shared Armando G. SalinasiD· 1 shared Braulio MuñoziD· 1 shared Caroline Filippi· 1 shared Christian PetersiD· 1 shared Denisse BascuñániD· 1 shared Eduardo J. Fernández-PéreziD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersNeuroscience

Nicolás Riffo-LepeORCID

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2 papers

Recent·Most cited

NeuroscienceNeurobiology of DiseasePeer-reviewedAug 7, 2026

Selective impairment of long-term depression in accumbal D1R+ MSNs involves calcium-permeable AMPARs in early Alzheimer's disease

Nicolás Riffo-Lepe, Juliana González-Sanmiguel, Isaias Meza…·Luis Gerardo Aguayo

This study identifies a cell-type-specific synaptic mechanism in the nucleus accumbens linking early Aβ accumulation to circuit dysfunction in early Alzheimer's disease.

DOI 10.1016/j.nbd.2026.107568

mouseexperimental assay

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NeurosciencebioRxivPreprintOct 16, 2020

Functional spreading of hyperexcitability induced by human and synthetic intracellular Aβ oligomers

Eduardo J. Fernández-Pérez, Braulio Muñoz, Denisse Bascuñán…·Luis Gerardo Aguayo

This study shows that intracellular Aβ oligomers increase neuronal hyperexcitability through synaptic mechanisms, spreading excitability across neural networks.

DOI 10.1101/2020.10.16.332445

humanelectronic health records

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