Nicolás Riffo-Lepe

Selective impairment of long-term depression in accumbal D1R+ MSNs involves calcium-permeable AMPARs in early Alzheimer's disease

This study identifies a cell-type-specific synaptic mechanism in the nucleus accumbens linking early Aβ accumulation to circuit dysfunction in early Alzheimer's disease.

Synapse specific alterations of autophagy are a hallmark of Danon disease

This study identifies synapse-specific autophagy alterations in Danon disease using a Xenopus tropicalis model, linking them to visual and cognitive impairments.

Functional spreading of hyperexcitability induced by human and synthetic intracellular Aβ oligomers

This study shows that intracellular Aβ oligomers increase neuronal hyperexcitability through synaptic mechanisms, spreading excitability across neural networks.