SPACE: multimodal spatial CRISPR screening with whole-transcriptome readout at subcellular resolution in 3D models
Mengwei Hu, Yi Cui, Qianhui Huang, Khoi Chu, Sierra Mckinzie, Michael J. Patrick, Sharanya Iyengar, Maerjianghan Abuduli, Marianne L. Spatz, Nandita Joshi, Brendan Miller, Shamsudheen Karuthedath Vellarikkal, Timothy Riordan, Danny A. Bitton, Jan Lubojacky, , Vanessa M. Peterson
SPACE enables spatial CRISPR screening with whole-transcriptome and protein readouts at subcellular resolution, revealing novel regulatory mechanisms in tumor microenvironments.
bioRxiv · Sep 14, 2025 · PreprintCell Biology