High-density extracellular recordings from the interior of intact brain organoids enable automated high-throughput functional assay
Fan Wu, Cuthbert Steadman, Liam P. Argent, Brian G. Jamieson, Shamsudheen Karuthedath Vellarikkal, Alex M. Tamburino, Iya G. Khalil, Vanessa M. Peterson, Matthew E Kennedy, Rebecca S. Mathew, Eran Stark, Bilal Çakır
This paper develops an automated system to record neural activity from brain organoids and uses it to classify organoids with Alzheimer's disease mutations using a classifier with 100% accuracy.
bioRxiv · Sep 12, 2025 · PreprintNeuroscience