Author

Michael J. Patrick

Nanostring Technologies (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Genomics· 2 Bioinformatics· 1 Cell Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:spatial transcriptomics· 7 Organism:human· 6 Approach:statistical model· 5 Research Focus:cell-cell communication· 4 Approach:experimental assay· 4 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Assay:bulk RNA-seq· 2

Frequent Co-Authors

Joseph BeechemiD· 6 shared Jason ReevesiD· 3 shared TYLER D. HETHERiD· 3 shared Aster Wardhani· 2 shared Dan McGuire· 2 shared Liuliu Pan· 2 shared Michael Rhodes· 2 shared Patrick J. DanaheriD· 2 shared

Activity by Year

2023-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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6 shared papersGenomics

Joseph BeechemORCID

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Author profile →

7 papers

Recent·Most cited

Breast cancer through the lens of whole transcriptome spatial imaging

Claire Williams, Yi Cui, Michael J. Patrick, Giang Ong, Terence C. Theisen, Megan Vandenberg, Joseph Beechem, Patrick J. Danaher

The paper uses spatial transcriptomics to analyze a breast tumor, identifying spatially distinct biological processes and potential therapeutic targets.

Scientific Reports · Sep 9, 2026Peer-reviewedCancer Biology

SPACE: multimodal spatial CRISPR screening with whole-transcriptome readout at subcellular resolution in 3D models

Mengwei Hu, Yi Cui, Qianhui Huang, Khoi Chu, Sierra Mckinzie, Michael J. Patrick, Sharanya Iyengar, Maerjianghan Abuduli, Marianne L. Spatz, Nandita Joshi, Brendan Miller, Shamsudheen Karuthedath Vellarikkal, Timothy Riordan, Danny A. Bitton, Jan Lubojacky, , Vanessa M. Peterson

SPACE enables spatial CRISPR screening with whole-transcriptome and protein readouts at subcellular resolution, revealing novel regulatory mechanisms in tumor microenvironments.

bioRxiv · Sep 14, 2025 · PreprintCell Biology

The Pdgfd-Pdgfrb axis orchestrates tumor-nerve crosstalk in pancreatic cancer

Peter L. Wang, Nicole A. Lester, Ella N. Perrault, Jennifer Su, Dennis H. Gong, Carina Shiau, Jingyi Cao, Phuong Trang Nguyen, Jung Woo Bae, Deniz Olgun, Hannah I. Hoffman, Ashley Lam, Jean Huang-Gao, Saifur Rahaman, Jimmy A. Guo, , William L. Hwang

This study identifies Pdgfd-Pdgfrb signaling as a driver of perineural invasion in pancreatic cancer by promoting cancer cell invasiveness and nerve engagement.

bioRxiv · Aug 26, 2025 · PreprintCancer Biology

The Spatial Atlas of Human Anatomy (SAHA): A Multimodal Subcellular-Resolution Reference Across Human Organs

Jiwoon Park, Roberto De Gregorio, Erika Hissong, Elif Ozcelik, Nicholas Bartelo, Felipe Segato Dezem, Luke Zhang, Maycon Marção, Hannah Chasteen, Yimin Zheng, Ernesto Abila, Junbum Kim, Theodore M. Nelson, Jacqueline Proszynski, Akua A. Agyemang, , Christopher E. Mason

SAHA creates a multimodal, subcellular-resolution reference atlas of healthy human tissues, revealing spatial organization and disease-associated disruptions across multiple organ systems.

bioRxiv · Jun 16, 2025 · PreprintSystems Biology

A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients

Yered H. Pita-Juárez, Dimitra Karagkouni, Nikolaos Kalavros, Johannes C. Melms, Sebastian Niezen, Toni Marie Delorey, Adam L. Essene, Olga Rachel Brook, Deepti B. Pant, Disha Skelton-Badlani, Pourya Naderi Yeganeh, Pinzhu Huang, Liuliu Pan, TYLER D. HETHER, Tallulah S. Andrews, , Ioannis S. Vlachos

This study creates a single-nucleus and spatial transcriptomic atlas of the COVID-19 liver, revealing cellular and functional disruptions associated with organ damage.

Genome biology · Mar 14, 2025Peer-reviewedGenomics

Sub-cellular Imaging of the Entire Protein-Coding Human Transcriptome (18933-plex) on FFPE Tissue Using Spatial Molecular Imaging

Rustem Khafizov, Erin Piazza, Yi Cui, Michael J. Patrick, Evelyn Metzger, Daniel McGuire, Dwayne L. Dunaway, Patrick J. Danaher, Margaret L. Hoang, Andrew Grootsky, Megan E. Grout, Shanshan He, Rachel Liu, Michael McKean, Michael Rhodes, Joseph Beechem

This paper introduces a high-plex spatial molecular imaging technique capable of sub-cellular transcriptome analysis of FFPE tissues, achieving whole transcriptome coverage with high resolution and minimal dissociation bias.

bioRxiv · Nov 27, 2024 · PreprintGenomics

InSituCor: a toolkit for discovering non-trivial spatial correlations in spatial transcriptomics

Patrick J. Danaher, Dan McGuire, Michael J. Patrick, David Kroeppler, Haiyan Zhai, Joachim Schmid, Joseph Beechem

InSituCor identifies non-trivial spatial correlations in spatial transcriptomics data by filtering out correlations explained by cell type landscapes.

bioRxiv · Sep 19, 2023 · PreprintBioinformatics