Author

J. A. Brennan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Organism:rat· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Assay:electrophysiology· 1

Frequent Co-Authors

I. R. Efimov· 3 shared A. Gams· 1 shared A. N. Miniovich· 1 shared B. C. Knollmann· 1 shared D. J. Blackwell· 1 shared D. Mendelowitz· 1 shared J. D. Schmeckpeper· 1 shared J. Dyavanapalli· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersPharmacology & Toxicology

I. R. Efimov

Mutual co-authors in cluster

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3 papers

Recent·Most cited

RyR2 inhibition with dantrolene is antiarrhythmic, antifibrotic, and improves cardiac function in chronic ischemic heart disease

J. D. Schmeckpeper, K. Kim, S. A. George, D. J. Blackwell, J. A. Brennan, I. R. Efimov, B. C. Knollmann

This study shows that dantrolene reduces ventricular tachycardia, fibrosis, and improves cardiac function in a mouse model of chronic ischemic heart disease.

bioRxiv · Jun 24, 2022 · PreprintPharmacology & Toxicology

Evidence of Superior and Inferior Sinoatrial Nodes in the Mammalian Heart

J. A. Brennan, Q. Chen, A. Gams, J. Dyavanapalli, D. Mendelowitz, W. Peng, I. R. Efimov

The paper identifies two distinct sinoatrial nodes in mammalian hearts, sSAN and iSAN, which control fast and slow heart rates under sympathetic and parasympathetic stimulation, respectively.

JACC: Clinical Electrophysiology · Dec 1, 2020Peer-reviewedPhysiology

Flexible and transparent silver nanowire structures for multifunctional electrical and optical biointerfacing

Z. Chen, N. Boyajian, Z. Lin, R. T. Yin, S. N. Obaid, J. Tian, J. A. Brennan, S. W. Chen, A. N. Miniovich, L. Lin, Y. Qi, X. Liu, I. R. Efimov, L. Lu

This paper develops flexible, transparent silver nanowire microelectrodes for multifunctional biointerfacing, showing high optical transparency, low impedance, and good biocompatibility in heart monitoring.

bioRxiv · Oct 10, 2020Bioengineering