Author

B. C. Knollmann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 3 Biophysics· 1 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Organism:mouse· 2 Assay:ATAC-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

D. J. Blackwell· 3 shared A. N. Smith· 2 shared J. A. Schwarz· 2 shared J. N. Johnston· 2 shared K. Kim· 2 shared R. L. Cornea· 2 shared A. Bertero· 1 shared A. C. Neininger· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersPharmacology & Toxicology

D. J. Blackwell

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Ryanodine receptor 2 inhibition reduces dispersion of cardiac repolarization, improves contractile function and prevents sudden arrhythmic death in failing hearts

P. Joshi, S. Estes, D. DeMazumder, B. C. Knollmann, S. Dey

eLife · Dec 11, 2023Peer-reviewedPhysiology

ent-Verticilide B1 inhibits type 2 ryanodine receptor channels and is antiarrhythmic in Casq2-/- mice

A. Gochman, T. Q. Do, K. Kim, J. A. Schwarz, M. P. Thorpe, D. J. Blackwell, A. N. Smith, W. S. Akers, R. L. Cornea, D. L. Laver, J. N. Johnston, B. C. Knollmann

This paper identifies ent-verticilide B1 as an antiarrhythmic compound that inhibits RyR2 channels and reduces arrhythmias in Casq2-/- mice.

bioRxiv · Jul 3, 2023 · PreprintPharmacology & Toxicology

RyR2 Binding of an Antiarrhythmic Cyclic Depsipeptide Mapped Using Confocal Fluorescence Lifetime Detection of FRET

J. Seflova, J. A. Schwarz, A. N. Smith, B. Svensson, D. J. Blackwell, T. A. Phillips, R. Nikolaienko, E. Bovo, R. T. Rebbeck, A. V. Zima, D. D. Thomas, F. Van Petegem, B. C. Knollmann, J. N. Johnston, S. L. Robia, R. L. Cornea

The paper maps the binding site of ent-verticilide on RyR2 using FRET and computational methods, identifying two potential loci within the RyR2 structure.

bioRxiv · Jun 22, 2023 · PreprintBiophysics

RyR2 inhibition with dantrolene is antiarrhythmic, antifibrotic, and improves cardiac function in chronic ischemic heart disease

J. D. Schmeckpeper, K. Kim, S. A. George, D. J. Blackwell, J. A. Brennan, I. R. Efimov, B. C. Knollmann

This study shows that dantrolene reduces ventricular tachycardia, fibrosis, and improves cardiac function in a mouse model of chronic ischemic heart disease.

bioRxiv · Jun 24, 2022 · PreprintPharmacology & Toxicology

Pharmacologic Therapy for Engraftment Arrhythmia Induced by Transplantation of Human Cardiomyocytes

K. Nakamura, L. E. Neidig, X. Yang, G. J. Weber, D. El-nachef, H. Tsuchida, S. Dupras, F. A. Kalucki, A. Jayabalu, A. Futakuchi-Tsuchida, D. S. Nakamura, S. Marchiano, A. Bertero, M. R. Robinson, K. Cain, , C. E. Murry

This study shows that amiodarone and ivabradine together prevent cardiac death and reduce arrhythmia burden in a porcine model of engraftment arrhythmia after human cardiomyocyte transplantation.

Stem Cell Reports · Oct 1, 2021Peer-reviewedPharmacology & Toxicology

MCL-1 inhibition by selective BH3 mimetics disrupts mitochondrial dynamics in iPSC-derived cardiomyocytes

M. L. Rasmussen, N. Taneja, A. C. Neininger, L. Wang, L. Shi, B. C. Knollmann, D. T. Burnette, V. Gama

This study shows that MCL-1 inhibition by BH3 mimetics disrupts mitochondrial dynamics and function in iPSC-derived cardiomyocytes, suggesting a non-apoptotic role for MCL-1 in cardiac health.

bioRxiv · Aug 22, 2019 · PreprintCell Biology