I. R. Efimov

Moderate Endurance Exercise Increases Arrhythmia Susceptibility and modulates Cardiac Structure and Function in a Sexually Dimorphic manner.

This study shows that moderate endurance exercise alters cardiac structure, function, and electrophysiology differently in male and female mice, increasing arrhythmia susceptibility in both sexes.

The role of structural vs cellular remodeling in arrhythmogenesis: personalized computer models of atrial fibrillation.

This study uses personalized computer models to analyze how structural and cellular changes contribute to atrial fibrillation, showing that electrophysiological remodeling influences arrhythmogenic substrate and driver locations.

Graphene Biointerface for Cardiac Arrhythmia Diagnosis and Treatment

This paper introduces a graphene biointerface for in vivo cardiac electrophysiology, demonstrating its use in sensing, stimulation, and treatment of arrhythmias.

RyR2 inhibition with dantrolene is antiarrhythmic, antifibrotic, and improves cardiac function in chronic ischemic heart disease

This study shows that dantrolene reduces ventricular tachycardia, fibrosis, and improves cardiac function in a mouse model of chronic ischemic heart disease.

Multifunctional flexible electro-optical arrays for simultaneous spatiotemporal cardiac mapping and modulation

This paper introduces flexible electro-optical devices for simultaneous cardiac mapping and modulation, demonstrating their functionality in real-time spatiotemporal control of cardiac activity.

Open-Source Low-Cost Cardiac Optical Mapping System

The paper presents a low-cost, open-source optical mapping system for cardiac electrophysiology with sufficient signal quality for drug studies in rodent hearts.

Simultaneous Triple-Parametric Optical Mapping of Transmembrane Potential, Intracellular Calcium and NADH for Cardiac Physiology Assessment

This study introduces triple-parametric optical mapping to simultaneously assess transmembrane potential, intracellular calcium, and NADH in cardiac tissue, demonstrating its use in drug testing and ischemia-reperfusion studies.

Evidence of Superior and Inferior Sinoatrial Nodes in the Mammalian Heart

The paper identifies two distinct sinoatrial nodes in mammalian hearts, sSAN and iSAN, which control fast and slow heart rates under sympathetic and parasympathetic stimulation, respectively.

Flexible and transparent silver nanowire structures for multifunctional electrical and optical biointerfacing

This paper develops flexible, transparent silver nanowire microelectrodes for multifunctional biointerfacing, showing high optical transparency, low impedance, and good biocompatibility in heart monitoring.

Personalization of mathematical models of human atrial action potential

The paper benchmarks two electrophysiological models of human atrial myocytes using genetic algorithm fitting of patch-clamp data, showing Maleckar model better captures heart rate dependence of APD and RP.

p38delta genetic ablation protects female mice from anthracycline cardiotoxicity

This study shows that deleting p38delta in female mice reduces anthracycline-induced cardiotoxicity by improving cardiac function and autophagy, while p38gamma deletion has no effect.

Genetic algorithm-based personalized models of human cardiac action potential

The paper develops a genetic algorithm to personalize cardiac action potential models using experimental data, achieving low error in waveform and duration predictions.

Dual cryo-radiofrequency ablation enhances lesion depth in beating human left ventricular preparations

This study compares four ablation protocols in human left ventricular tissue, finding that cryo-radiofrequency ablation (CR-RF) produces the deepest lesion.