Author

S. A. George

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Bioengineering· 1 Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Assay:imaging· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

I. R. Efimov· 4 shared A. Kiss· 1 shared A. Venegas· 1 shared B. C. Knollmann· 1 shared C. Wei· 1 shared D. J. Blackwell· 1 shared J. A. Brennan· 1 shared J. D. Schmeckpeper· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersPhysiology

I. R. Efimov

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Moderate Endurance Exercise Increases Arrhythmia Susceptibility and modulates Cardiac Structure and Function in a Sexually Dimorphic manner.

S. A. George, K. A. Trampel, K. Brunner, I. R. Efimov

This study shows that moderate endurance exercise alters cardiac structure, function, and electrophysiology differently in male and female mice, increasing arrhythmia susceptibility in both sexes.

bioRxiv · Aug 21, 2023Physiology

Identification of novel oncogenic transcriptional targets of mutant p53 in Esophageal Squamous Cell Carcinoma

S. A. George, V. Kotapalli, P. Ramaswamy, R. Kumar, S. Gowrishankar, S. G. Uppin, M. D. Bashyam

This study identifies novel oncogenic targets of rare non-hotspot p53 mutations in ESCC and validates their functional roles in tumorigenesis.

bioRxiv · Mar 12, 2023 · PreprintCancer Biology

RyR2 inhibition with dantrolene is antiarrhythmic, antifibrotic, and improves cardiac function in chronic ischemic heart disease

J. D. Schmeckpeper, K. Kim, S. A. George, D. J. Blackwell, J. A. Brennan, I. R. Efimov, B. C. Knollmann

This study shows that dantrolene reduces ventricular tachycardia, fibrosis, and improves cardiac function in a mouse model of chronic ischemic heart disease.

bioRxiv · Jun 24, 2022 · PreprintPharmacology & Toxicology

Simultaneous Triple-Parametric Optical Mapping of Transmembrane Potential, Intracellular Calcium and NADH for Cardiac Physiology Assessment

S. A. George, Z. Lin, I. R. Efimov

This study introduces triple-parametric optical mapping to simultaneously assess transmembrane potential, intracellular calcium, and NADH in cardiac tissue, demonstrating its use in drug testing and ischemia-reperfusion studies.

bioRxiv · Sep 9, 2021Bioengineering

p38delta genetic ablation protects female mice from anthracycline cardiotoxicity

S. A. George, A. Kiss, S. N. Obaid, A. Venegas, T. Talapatra, C. Wei, T. Efimova, I. R. Efimov

This study shows that deleting p38delta in female mice reduces anthracycline-induced cardiotoxicity by improving cardiac function and autophagy, while p38gamma deletion has no effect.

bioRxiv · Mar 2, 2020Physiology