Chromosomal instability mediates immune exclusion and response to cytotoxic chemotherapy in colorectal liver metastases
C. A. Martinez, L. F. Spurr, S. C. Iyer, S. A. Pugh, J. A. Bridgewater, J. N. Primrose, E. Domingo, T. S. Maughan, M. I. D'Angelica, M. Talamonti, M. C. Posner, P. P. Connell, R. R. Weichselbaum, S. P. Pitroda
This study shows that chromosomal instability (CIN) in colorectal liver metastases leads to immune exclusion and poor prognosis but increases sensitivity to DNA-damaging therapies.
bioRxiv · Sep 22, 2021 · PreprintCancer Biology