Phage display uncovers a sequence motif that drives polypeptide binding to a conserved regulatory exosite of O-GlcNAc transferase
M. G. Alteen, R. W. Meek, S. Kolappan, J. A. Busmann, J. Cao, Z. O'Gara, R. Derda, G. J. Davies, D. J. Vocadlo
The paper identifies a peptide sequence motif that binds to OGT's exosite, causing allosteric inhibition through steric occlusion of the active site.
bioRxiv · Mar 15, 2023 · PreprintBiochemistry