Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
5 papers
Recent·Most cited
M. G. Alteen, R. W. Meek, S. Kolappan, J. A. Busmann, J. Cao, Z. O'Gara, R. Derda, G. J. Davies, D. J. Vocadlo
The paper identifies a peptide sequence motif that binds to OGT's exosite, causing allosteric inhibition through steric occlusion of the active site.
bioRxiv · Mar 15, 2023 · PreprintBiochemistry
J. Li, M. Sharma, R. W. Meek, A. Alhifthi, Z. Armstrong, N. Madiedo Soler, M. Lee, E. D. Goddard-Borger, J. N. Blaza, G. J. Davies, S. J. Williams
This paper reports the cryo-EM structure and kinetics of sulfolactaldehyde dehydrogenase from Rhizobium leguminosarum, revealing its cofactor usage and catalytic mechanism in sulfolactate synthesis.
bioRxiv · Mar 13, 2023 · PreprintBiochemistry
R. Lipsh-Sokolik, O. Khersonsky, S. P. Schroder, C. de Boer, S. Y. Hoch, G. J. Davies, H. S. Overkleeft, S. J. Fleishman
The paper introduces CADENZ, a machine-learning strategy for designing structurally diverse enzymes, achieving a tenfold improved hit rate and over 10,000 active enzymes.
bioRxiv · Sep 17, 2022Bioengineering
L. F. Sobala, P. Z. Fernandes, Z. Hakki, A. J. Thompson, J. D. Howe, M. Hill, N. Zitzmann, S. Davies, Z. Stamataki, T. D. Butters, D. S. Alonzi, S. J. Williams, G. J. Davies
The paper reports the structure of human MANEA and inhibitor complexes, revealing its mechanism and informing the development of antiviral agents against bovine viral diarrhea and dengue viruses.
bioRxiv · Jun 30, 2020Biochemistry
J. Li, R. Epa, J. P. Lingford, N. Scott, D. Skoneczny, M. Sharma, A. J. Snow, E. D. Goddard-Borger, G. J. Davies, M. J. McConville, S. J. Williams
This paper identifies a sulfoglycolytic Entner-Doudoroff pathway in Rhizobium leguminosarum that allows growth on sulfoquinovose, producing sulfolactate and contributing to bacterial persistence in soil.
bioRxiv · Dec 17, 2019Microbiology