The IFIH1-A946T risk variant promotes diabetes in a sex-dependent manner
A. J. Stock, P. Gonzalez-Paredes, L. Previato de Almeida, S. D. Kosanke, S. Chetlur, H. Budde, P. Wakenight, T. A. Zwingman, A. B. Rosen, E. Allenspach, K. J. Millen, J. H. Buckner, D. J. Rawlings, J. A. Gorman
This study shows the IFIH1-A946T risk variant increases T1D risk in females but not males by enhancing IFN I signaling and altering immune cell profiles in NOD mice.
bioRxiv · Jan 20, 2024Immunology