Author

J. A. Machado-Neto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

A. M. de Leal· 1 shared A. P. A. d. L. Lange· 1 shared D. A. Pereira-Martins· 1 shared D. V. Wilke· 1 shared E. A. Edson· 1 shared E. D. R. P. Velloso· 1 shared E. Griessinger· 1 shared E. M. Rego· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperPharmacology & Toxicology

A. M. de Leal

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The PIP4K2 inhibitor THZ-P1-2 exhibits antileukemia activity by disruption of mitochondrial homeostasis and autophagy

K. Lima, D. A. Pereira-Martins, L. B. L. de Miranda, J. L. Coelho-Silva, G. d. S. Leandro, I. Weinhauser, R. d. C. Cavaglieri, A. M. de Leal, W. F. da Silva, A. P. A. d. L. Lange, E. D. R. P. Velloso, E. Griessinger, J. R. Hilberink, G. Huls, J. J. Schuringa, , J. A. Machado-Neto

This study shows that THZ-P1-2, a PIP4K2 inhibitor, kills leukemia cells by disrupting mitochondrial homeostasis and autophagy, with minimal effects on healthy cells.

bioRxiv · Aug 20, 2022Pharmacology & Toxicology

Chromomycin A5 induces bonafide immunogenic cell death in metastatic melanoma

K. G. D. Florencio, E. A. Edson, F. d. C. L. Pinto, O. D. L. Pessoa, J. A. Machado-Neto, D. V. Wilke

This study shows that Chromomycin A5 induces immunogenic cell death in metastatic melanoma cells, as evidenced by DAMP release and immune activation in vivo.

bioRxiv · Sep 18, 2021 · PreprintImmunology

The U2AF homology motif kinase 1 (UHMK1) is upregulated upon hematopoietic cell differentiation

I. Barbutti, J. A. Machado-Neto, V. C. Arfelli, P. de Melo Campos, F. Traina, S. T. Olalla Saad, L. Froehlich Archangelo

This study shows UHMK1 is upregulated during hematopoietic differentiation and its knockdown increases clonogenicity in leukemia cells.

bioRxiv · Sep 11, 2017Cancer Biology