Allosteric site variants affect GTP hydrolysis on RAS
C. W. Johnson, S. K. Fetics, K. P. Davis, J. A. Rodrigues, C. Mattos
The paper investigates how mutations in an allosteric site of HRAS affect GTP hydrolysis and shows that structural changes correlate with enzymatic activity and RAF-RBD binding.
bioRxiv · May 29, 2023Biochemistry