Author

C. W. Johnson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

C. Mattos· 2 shared K. M. Haigis· 2 shared A. G. Stephen· 1 shared A. Liu· 1 shared B. Hunt· 1 shared C. B. Marshall· 1 shared D. K. Morrison· 1 shared D. K. Simanshu· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

C. Mattos

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

How Fungi Biosynthesize 3-Nitropropanoic Acid: the Simplest yet Lethal Mycotoxin

C. W. Johnson, M. Ohashi, Y. Tang

The paper identifies the biosynthetic pathway for 3-NPA in Aspergillus oryzae using genome mining, genetic inactivation, and biochemical analysis.

bioRxiv · Feb 22, 2024Biochemistry

Allosteric site variants affect GTP hydrolysis on RAS

C. W. Johnson, S. K. Fetics, K. P. Davis, J. A. Rodrigues, C. Mattos

The paper investigates how mutations in an allosteric site of HRAS affect GTP hydrolysis and shows that structural changes correlate with enzymatic activity and RAF-RBD binding.

bioRxiv · May 29, 2023Biochemistry

Allosteric regulation of switch-II controls K-Ras oncogenicity

M. H. Yang, T. H. Tran, B. Hunt, R. Agnor, C. W. Johnson, T. J. Waybright, J. A. Nowak, A. G. Stephen, D. K. Simanshu, K. M. Haigis

This study shows that the K104Q mutation reduces oncogenic K-Ras activity in vivo by disrupting GEF-mediated nucleotide exchange and stabilizing switch-II helix through an allosteric network.

bioRxiv · Sep 20, 2022 · PreprintCancer Biology

Regulation of GTPase function by autophosphorylation

C. W. Johnson, H.-S. Seo, E. M. Terrell, F. KleinJan, T. Gebregiworgis, G. M. C. Gasmi-Seabrook, E. A. Geffken, J. Lakhani, K. Song, O. Popow, J. A. Paulo, A. Liu, C. Mattos, C. B. Marshall, M. Ikura, , K. M. Haigis

This study shows autophosphorylation of small GTPases like H-RAS and K-RAS alters their nucleotide exchange and effector interactions, changing their functional behavior.

bioRxiv · Jun 23, 2021Biochemistry